MTHFR (rs1801133) and SERPINE1/PAI-1 (−675 4G/5G) gene polymorphisms and their association with spontaneous abortion and missed pregnancy in an ethnic Uzbek population: a case–control study
Spontaneous abortion and missed (non-developing) pregnancy are common early reproductive losses in which disturbed folate metabolism and inherited thrombophilia are implicated. Variants of methylenetetrahydrofolate reductase ( MTHFR ) and of the plasminogen activator inhibitor-1 gene ( SERPINE1 /PAI-1) may increa...