Open access
Sep 2026
Local translation couples synaptic activity to mitochondrial adaptation in dendrites
This work identifies eIF4G2-dependent local translation as a mechanism that establishes mitochondrial competence during synaptic activity by coordinating the production of mitochondrial proteins and uORF-encoded micropeptides to remodel local mitochondria.
Madison T. Jones, N. Noble, Robert B. Darnell et al.
· bioRxiv · 0 citations