Author

N. Otani

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Case report Open access Oct 2026

A case of renal hypouricemia type 1 associated with compound heterozygous URAT1/SLC22A12 variants A209V and F379L: clinical evidence for their pathogenic significance

The severe hypouricemia and excessive urinary uric acid excretion observed in this patient provide clinical evidence supporting the pathogenic significance of the A209V and F379L combination and suggest that urinary alkalization may be beneficial in the management of nephrolithiasis associated with RHUC.

N. Otani, M. Yamamoto, T. Takata et al. · CEN Case Reports · 0 citations

Open access Jul 2026

Quantitative assessment of systolic and diastolic left ventricular energy loss using vector flow mapping in healthy participants: a retrospective observational study

VFM-derived EL exhibits age-related, phase-dependent changes characterized by a selective increase in systolic EL and altered phase distribution in healthy participants, indicating that age-related differences in EL persisted after normalization.

N. Otani, Haruka Noma, Harunori Takahashi et al. · Cardiovascular Ultrasound · 0 citations