Open access
Sep 2026
Toward Advanced Quantitative Prediction of Missense Variant Effects
Predicting how missense variants alter protein function is central to resolving the genotype-to-phenotype equation, a task now addressed by numerous computational predictors. The most accurate are increasingly opaque, however, limiting both their mechanistic value and their adoption in the clinic. Here we present QAFIs...
Shao-Pei Ye, Selen Özkan, Aitana Díaz-Vásquez et al.
· International Journal of Mol... · 0 citations