Crimean-Congo hemorrhagic fever virus (CCHFV) is a WHO-priority pathogen with high mortality and wide global distribution. A major challenge in CCHFV vaccine development is identifying antigens that induce functional cellular and humoral immunity. We previously showed that the CCHF nucleoprotein (NP) elicits protective...
Jing-Yi Yan, Lara Sweetapple, Christian An Bính Nordentoft et al.· bioRxiv· 0 citations
Plasmodium vivax (Pv) remains the primary cause of malaria outside Africa, yet no licensed vaccine is available against this pathogen. Here, we evaluate the immunogenicity and protective efficacy of novel vaccines targeting E140, a recently identified multi-stage antigen conserved across Plasmodium species. Lipid nanop...
R. F. Marques, Guilherme Antonio de Souza Silva, Vitor Antunes da Silva et al.· Molecular Therapy: Nucleic A...· 0 citations
It is demonstrated that the amount of PEG-lipid used in the LNP formulation has a significant impact on humoral immune responses to mRNA-LNP vaccines in mice and can impact memory B cell responses.
Emily F. Daley, Máté Vadovics, F. Coirada et al.· Journal of Immunology· 0 citations
It is demonstrated that the optimal induction of CD8 T-cells requires IFN-I signaling in multiple myeloid cell types, not just in CD8 T-cells, dendritic cells, or monocytes, and that regulation of IFN-β by NF-κB and all IFN-I subtypes by IRF is required to induce protective CD8 T-cells.
Samit Kafle, Brian Montoya, Carolina R. Melo-Silva et al.· Journal of Immunology· 0 citations
The dsRNA-LNP acts as a potent adjuvant for nucleoside-modified mRNA vaccination, inducing a strong immune activation, representing a potent platform for eliciting balanced, durable antiviral immunity.
F. Coirada, Nelson Cortes Oliveira, Emily F. Daley et al.· Journal of Immunology· 0 citations
It is demonstrated that antigenic clade-matching is likely critical for protection against H5N1 and suggest that currently stockpiled H5N1 vaccines may not protect against contemporary viruses.
E. Gary, Nicholas J. Tursi, Casey E. Hojecki et al.· Journal of Immunology· 0 citations
The V1V2 mRNA-LNP vaccine is highly immunogenic in mice and rhesus macaques, eliciting cross-clade functional antibodies capable of recognizing native Env, and may provide insights relevant to vaccine testing against other pathogens.
Catarina E. Hioe, Xiao-Mei Liu, C. Yengo et al.· Journal of Immunology· 0 citations
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