Early-childhood temperament is associated with later mental health. Temperament continues to develop throughout the first years of life, and a single assessment cannot capture its trajectory. Whether departures from an individual's developmental trajectory carry psychiatric risk remains unknown. Using data from more th...
J. Kopal, N. Bakken, P. Parekh et al.· Molecular Psychiatry· 0 citations
By dissecting the genetic liability to SUD and SU and investigating their relationship with BIP, this work finds a genetic signature correlated with substance dependence but not substance use more broadly.
L. Ystaas, P. Parekh, N. Parker et al.· Biological Psychiatry· 0 citations
Bipolar disorder’s genetic architecture appears hierarchical—a general liability resolving into dimensions of course and comorbidity, beyond subtypes, beyond subtypes.
Tracey van der Veen, M. Tesfaye, J. M. K. Yang et al.· Research Square· 0 citations
This work derived cortical brain organoids from a large cohort of schizophrenia (SCZ) patients and healthy controls and employed a comprehensive multiomics strategy to dissect the cellular mechanisms of long-term CLZ exposure, uncovered a SCZ-specific and metabolism-independent alternative splicing program that was ame...
I. Akkouh, Jordi Requena Osete, A. Szabo et al.· bioRxiv· 0 citations
It is found that schizophrenia and ADHD show distinct genetic patterns: schizophrenia shares more genetic factors with brain structure and diabetes, while ADHD is more strongly linked to metabolic pathways.
J. Kopal, A. Shadrin, D. van der Meer et al.· Communications Medicine· 0 citations
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