N. Penzel

Disentangling white matter correlates of symptom severity and general impairment in early psychosis.

White matter (WM) alterations are well documented in individuals at clinical high-risk for psychosis (CHR-P) and with recent-onset psychosis (ROP), yet it remains unclear whether they reflect vulnerability, psychosis-related symptom severity, or general impairments shared with other disorders such as depression. To dis...

Unraveling Suicidal Ideation and Behaviors in a Global Cohort of Individuals at Clinical High-Risk for Psychosis: Multivariable Correlates and Subthreshold Psychotic Symptoms.

INTRODUCTION Suicidal ideation and behaviors (SIB) are common among individuals at clinical high risk for psychosis (CHR-P), but their relationship with the overall clinical profile remains unclear. This study aimed to identify sociodemographic/clinical factors associated with SIB in CHR-P individuals and to examine wh...

Adolescent trajectories of psychotic-like experiences and autistic traits and their association with cognition, environmental adversity, and white matter microstructure in the ABCD Study.

BACKGROUND Psychotic-like experiences (PLEs) and autistic traits across development are associated with poor mental health outcomes. However, the relationship between PLEs and autistic traits, and their links with clinical and biological predictors of longitudinal outcomes, remain poorly understood. METHODS PLEs and...

The Coupled Stochastic Dynamical System: A Generative Model for Simulating and Forecasting Youth Mental Health Trajectories