Author

N. Pinotsis

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Open access Aug 2026

Allosteric capsid inhibitors and their escape mutants drive HIV-1 sensing

Small-molecule capsid inhibitors suppress HIV-1 infectivity by binding to capsid at the same site as FG motif-bearing host cofactors Sec24C, NUP153, CPSF6 and disordered nucleoporins residing in the nuclear pore complex central channel. We have used rational design to develop inhibitors called “allosteres” that target...

Kate L. Morling, Morten L. Govasli, Ben Graham et al. · bioRxiv · 0 citations

Open access Jul 2026

Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy

It is established that HCM-linked ACTN2 variants compromise protein integrity through multiple mechanisms, highlight the ABD as a hotspot of vulnerability and provide a potential framework for interpreting cardiomyopathy-associated variants.

Maya Noureddine, H. Mikolajek, Nathan Cowieson et al. · Nature Communications · 0 citations