Design and Validation of a Reverse Phase HPLC Method for Simultaneous Determination of Doxycycline and Metronidazole in Targeted Periodontal Therapy
The reverse-phase high-performance liquid chromatography (RP-HPLC) method has been shown to exhibit excellent repeatability, accuracy, and reproducibility when used to simultaneously assess doxycycline and metronidazole for the management of localised periodontal diseases.Low levels of interference were achieved throug...