Open access
Aug 2026
Regulated HSPG Signaling Directs Epicardial Behavior to Support Cardiac Formation
BACKGROUND: Pathways controlling cardiac cell behavior share a common dependency on heparan sulfate proteoglycans (HSPGs), which tightly regulate signaling at extracellular locations. This signaling is essential for cardiac development, yet how HSPGs are regulated in the forming heart is unknown. The epicardium is a ri...
A. Redpath, Irina-Elena Lupu, Louis Haffreingue et al.
· Circulation Research · 0 citations