Sep 2026
From Inhibitor to Reporter: Nirmatrelvir-Derived Fluorogenic Substrates for the SARS-CoV-2 Main Protease.
A library of fluorogenic substrates, structurally derived from the well-established Mpro substrate Boc-Abu-Tle-Leu-Leu-Gln-AMC and the clinically approved covalent-reversible Mpro inhibitor nirmatrelvir, was created to optimize assays for highly active Mpro inhibitors by providing Mpro substrates with improved kinetic...
R. Voget, Victoria Steiger, Katharina Sylvester et al.
· ACS Chemical Biology · 0 citations