Breast cancer remains a significant clinical challenge, particularly in triple‑negative breast cancer (TNBC), in which therapeutic resistance limits treatment efficacy. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising strategy to overcome resistance in...
S. Mohammad, A. Vasudevan, Samreet Raizal Rodrigues et al.· Asia-Pacific Journal of Clin...· 0 citations
Hepatocellular carcinoma (HCC) develops within a chronically inflamed and immunologically dysregulated hepatic microenvironment that contributes to therapeutic resistance and disease progression. Gasdermin-mediated pyroptosis has emerged as a context-dependent inflammatory cell-death program capable of reshaping antitu...
T. Alramadneh, Inoyatillo Kholmurodov, Naina Boboyeva et al.· Clinical Immunology· 0 citations
Corynoline is a naturally occurring benzophenanthridine-derived alkaloid widely isolated from plants of the genus Corydalis, which have been used for centuries in traditional herbal medicine for the management of inflammation, pain, and infectious diseases. Belonging to the structurally unique benzophenanthridine class...
N. Tailor· Mini-Reviews in Medical Chem...· 0 citations
Astrocyte-elevated gene-1 (AEG-1), also known as metadherin (MTDH), is a pleiotropic oncogene critically involved in the onset and development of glioblastoma (GBM), other malignant gliomas, and neuroblastoma. Its expression is upregulated under hypoxic conditions and during glucose deprivation, enabling tumor cells to...
S. Mohammad, A. Vasudevan, M. Al-Khreisat et al.· Tissue & Cell· 0 citations
Ferroptosis, an iron‐dependent form of regulated cell death, is frequently dysregulated in both tumor and immune cells, contributing to tumor progression and limiting the effectiveness of cancer immunotherapy. Defining the molecular mechanisms that govern ferroptosis and its effects within the tumor immune microenviron...
Usamah Sayed, J. Rizaev, R. Turaev et al.· Journal of Cellular Biochemi...· 0 citations
Natural killer (NK) cells are critical components of the innate immune system, renowned for their ability to recognize and eliminate malignant and infected cells without prior sensitization. NK cell immunotherapy encompasses various approaches, including adoptive transfer of ex vivo expanded NK cells, cytokine stimulat...
Amr A. El-Sehrawy, M. Al-Khreisat, Jalpa R. Patel et al.· Cancer Immunology and Immuno...· 0 citations
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease are among the progressive disorders of the nervous system that are characterized by the gradual destruction of neurons, the accumulation of misfolded proteins, and the limited effectiv...
S. Mohammad, A. Vasudevan, G. Oriquat et al.· Behavioural Brain Research· 0 citations
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