The type VI secretion system (T6SS) is a molecular harpoon used by 19% of sequenced bacteria to inject toxic proteins into microbial competitors or host cells. Despite its widespread distribution, many T6SS effectors (T6Es) remain unidentified in bacterial genomes. Here, we developed an XGBoost classifier integrating 4...
Avital Akerman-Arad, A. Danov, Yuval Chausho et al.· bioRxiv· 0 citations
This work combines comparative genomics, glycoproteomics, cryo-EM, and antigenic characterization to define the structural mechanisms underlying spike evolution across representative BCoV lineages and establishes a mechanistic framework for Embecovirus spike evolution.
Haneen Tarabih, Jimmy Asiku, Y. Levi-Kalisman et al.· bioRxiv· 0 citations
This study illustrates how alternative antibody repertoires can reveal functionally important antigenic surfaces that are underrepresented in conventional human antibody responses, providing new opportunities for the rational design of next-generation HCV vaccine immunogens.
A scalable and adaptable microbial biotechnology platform for the scalable recombinant production of highly toxic bacterial proteins based on transient intramolecular toxin neutralization and the integration of transient intramolecular neutralization with computational engineering is presented.
R. Fraenkel, Inbar Cahana, Tomer Sivan et al.· bioRxiv· 0 citations
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