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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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N. Ujiantari

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Open access Sep 2026

α-Chaconine as a Potential Inhibitor of Mutant Phosphatidylinositol 3-Kinase Alpha in Breast Cancer Stem Cells: Insights from Structure Prediction and Molecular Dynamics.

INTRODUCTION Breast cancer stem cells (BCSCs) promote chemoresistance and metastasis by activating aberrant signaling pathways such as phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt). α-Chaconine (CHA) is a steroidal glycoalkaloid that has demonstrated cytotoxic and antiproliferative activity in various cance...

B. Saputra, N. Ujiantari, Badra Sanditya Rattyananda et al. · 0 citations

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