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N. V. Bathula

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Jul 2026

Transgene Sequence Codon Optimization and Composition Determines Replication Competence of Self-Amplifying RNA.

An underappreciated constraint in saRNA therapeutics is defined and saRNA-specific payload design frameworks that incorporate alphavirus associated compositional biases during transgene sequence optimization are motivated.

N. V. Bathula, Shekinah K V Soriano, Cynthia Huang et al. · 1 citation