Whole mRNA expression of blood PBMCs identified RHOA, CDH1, and enrichment of pathways leading to neutrophil recruitment and inflammatory response in granulomatosis with polyangiitis.
Granulomatosis with polyangiitis (GPA) is a rare, complex autoimmune vasculitis. Investigating the differential mRNA expression signature in PBMCs may identify critical gene(s) implicated in GPA. This study recruited 21 GPA patients and 23 healthy controls of North Indian origin. Whole mRNA was isolated from PBMCs, and...