Biological aging occurs heterogeneously across individuals and organs. However, current measures of biological age incompletely capture organ-specific differences in health and disease risk. Because chest CT visualizes multiple thoracic organs, it offers an opportunity to quantify structural aging across organ systems....
J. Sato, M. Salehjahromi, A. Zafar et al.· medRxiv· 0 citations
Extending durable benefit and achieving cure in a broader population will require a deeper understanding of mechanisms of resistance, the development of novel immunotherapeutics, and more precise personalization of treatment strategies.
D. Boiarsky, N. Vokes· Cancer Journal· 0 citations
INTRODUCTION
Homozygous deletion of 9p21, containing CDKN2A/B and MTAP (CMdel), underlies emerging therapeutic strategies including PRMT5/MAT2A inhibition. The clinicogenomic context and treatment outcomes of CMdel in NSCLC remain incompletely defined.
METHODS
We analyzed Tempus Lens records with paired DNA/RNA seque...
N. Vokes, J. Symons, Brooke Rhead et al.· Clinical Cancer Research· 0 citations
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