Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice
Inhibition of orphan GPCR dimerization by small molecules is feasible and improves infection control and arterial hypertension.
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Inhibition of orphan GPCR dimerization by small molecules is feasible and improves infection control and arterial hypertension.
This work explores structure-based strategies to identify small-molecule agonists of neurotensin (NTS) receptors, leading to the discovery of potent agonists with in vivo antinociceptive effects and to insights into the molecular basis of receptor activation.
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