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Open access Sep 2026

260. Prescription medication use, healthcare utilisation and genetic risk for addiction: a phenome-wide association and Mendelian randomization study

Abstract Background Substance Use Disorders (SUDs) are major contributors to global morbidity and premature mortality. While their adverse physical and psychiatric sequalae are widely attributed to toxic effects of substance exposure, accumulating evidence suggests that inherited liability to addiction also shapes broa...

M. Graczyk, C. Albiñana, A. Lee et al. · 0 citations
Open access Aug 2026

Polygenic and familial contributions to antidepressant continuation, switching, discontinuation and augmentation in the All of Us and Pharmlines cohorts

Predicting antidepressant response remains a major challenge, and it is unclear whether reported polygenic associations reflect drug-specific non-response or a broader propensity for treatment modification. We analysed participants with at least one antidepressant monotherapy episode of [≥]28 days in the All of Us (AoU...

A. Walker, X. Wang, J. Bos et al. · 0 citations
#machine learning Preprint Aug 2026

Learning Human Health and Diseases from 24-hour Wrist Movement

These findings establish 24-hour wrist movement as a rich and scalable source of health information, with the potential to support passive health monitoring and disease prediction at population scale, and establish Sensori, a self-supervised foundation model that learns general-purpose health representations directly f...

Yong Wang, D. McGagh, K. Broomberg et al. · 0 citations

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