N. Zabet

A Framework for Quantifying DNA Methylation Heterogeneity and Detecting Co-methylated loci from Native Nanopore Sequencing

DNA methylation is an important epigenetic mechanism involved in gene regulation. Most methods focus on analysing DNA methylation averaged from multiple reads, yet these average methylation profiles obscure heterogeneity between individual DNA molecules and coordinated methylation states across loci. Native Oxford Nano...