Open access
Oct 2026
The Architecture of Selectivity: Molecular Basis of BlTx2 Discrimination Among Kv Channels and Kv4 Isoforms
Kv4 channels generate transient A-type potassium currents, but the contribution of Kv4.1 remains difficult to define because few pharmacological tools discriminate among Kv4 isoforms. We investigated the molecular basis of Kv4.1-selective inhibition by BlTx2, an α-KTx15 scorpion toxin from Buthacus leptochelys. Using e...
Y. Levy, Ayalon Reis, G. Blecher et al.
· Toxins · 0 citations