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Author

Na Liu

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Open access Sep 2026

HDAC4 drives ferroptosis and fibrosis by inhibiting Foxo3a-GPX4 axis during AKI–CKD progression

Histone deacetylase 4 (HDAC4) modifies both histone and non-histone proteins, but its role in the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) remains unclear. Here, we investigated the function and mechanism of HDAC4 in ischemia-reperfusion (IR)-induced AKI-CKD progression using Tasquini...

Feng-Chen Shen, Lin Hu, Xin-Yu Du et al. · 0 citations
Open access Aug 2026

Ubiquitin-Specific Protease 11 Promotes Uric Acid-Induced Renal Tubular Epithelial Cell Apoptosis via Deubiquitinating P53 and Enhancing Mitochondrial Outer Membrane Permeabilization

The results underscore the pivotal role of USP11 in TEC apoptosis during CKD progression and suggest that targeting USP11 represents a potential therapeutic approach for CKD patients.

Ying-Feng Shi, Jinqing Li, Na Liu · 0 citations

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