Open access
Aug 2026
High-resolution mapping of embryonic genome activation unveils a decoupling of transcription activation from precocious H3K4me3 removal
The results indicate that precocious removal of H3K4me3 from embryonic chromatin only modestly affects embryonic transcription without perturbing EGA timing, arguing against a major instructive role of precocious remodeling of maternally inherited H3K4me3 after fertilization on genome activation.
Jasmina Al-Mousawi, Luca Michetti, Laura Castaldi et al.
· Science Advances · 1 citation
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