Na Wang

Targeting PCK2 alleviates GERD by suppressing MAPK-dependent endoplasmic reticulum stress and oxidative stress-induced apoptosis.

Gastroesophageal reflux disease (GERD) is a digestive disease characterized by endoplasmic reticulum stress (ERS) imbalance and oxidative stress-induced cellular injury. However, the key ERS-related regulators involved in GERD progression remain unclear. Here, we identified PCK2 as a novel GERD-associated ERS regulator...