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Sep 2026

Daidzein protected against sepsis-induced acute lung injury by suppressing pyroptosis via activation of estrogen receptor-β.

Sepsis-induced acute lung injury (SI-ALI) carries an extremely high mortality rate. Daidzein is a natural phytoestrogen with anti-inflammatory properties. Estrogen receptor β (ERβ) is a potential target for inflammatory regulation. However, whether Daidzein protects against cecal ligation and puncture (CLP)-induced ALI...

He-Jun Gao, Mei-Ru Song, Ke-Shi Hu et al. · 0 citations
Open access Sep 2026

Salvianolic Acid B Inhibits Ferroptosis in Acute Lung Injury: Network Analysis and Experimental Validation

ABSTRACT This current study aimed to decipher the anti‐inflammatory, anti‐ferroptosis and pronounced lung‐protective activities of Salvianolic acid B (Sal B) by integrating network pharmacology and experimental confirmation across multiple aspects. The optimal target protein and the relevant molecular mechanisms for Sa...

He-Jun Gao, Ren-Hui Xiong, Na Yue et al. · 0 citations

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