Author

Nader Aryamanesh

2 papers indexed here

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Open access Aug 2026

MUTYH Activity Maintains Telomere Stability in Response to Chronic Telomeric 8-Oxoguanine Damage in Cancer Cells

Telomeres are highly susceptible to oxidative DNA damage, particularly 8-oxoguanine (8-oxoG), which is processed by glycosylase-initiated base excision repair (BER). OGG1 removes 8-oxoG opposite C, and MUTYH removes A misinserted opposite 8-oxoG to prevent mutations. While OGG1 has an established role in telomere prote...

Mariarosaria de Rosa, Theresa M. Heidenreich, Libby Childs et al. · Biomolecules · 0 citations

Open access Sep 2026

Culture media alter retinal organoid physiology promoting AAV transduction and retinal ganglion cell survival.

Human iPSC-derived retinal organoids offer a human-relevant platform for inherited retinal disease (IRD) gene therapy, yet robust AAV transduction in vitro remains challenging. Here we show that culture in BrainPhys™ (BP) medium markedly enhances AAV-mediated gene delivery. Brief BP exposure during the transduction win...

Michelle O'Hara-Wright, Benjamin Y. Lim, Melissa M. Mangala et al. · Gene Therapy · 0 citations