A-88: DOPA Decarboxylase Relates to Hippocampal Atrophy and Amplifies Tau-Associated Memory Dysfunction in Older Women at Risk for Alzheimer’s Disease
Objective: Cerebrospinal fluid (CSF)-derived DOPA decarboxylase (DDC) is a promising biomarker of synucleinopathy; however, its relevance in Alzheimer’s disease (AD)-risk cohorts remains unclear. Research suggests that DDC may index co-pathology contributing to neurodegeneration and memory dysfunction beyond AD patho...