Nai-Xin Cao

Integrative scRNA-seq and scTCR-seq analyses decode dual TCR γδ T-cell characteristics in human and mouse

Abstract The clonal selection theory of “one lymphocyte expresses one type of antigen receptor” has been challenged and complemented by the concept of dual receptor lymphocytes. However, the proportion, source, and characterization of dual TCR γδ T cells have not been determined. Using single-cell RNA plus single-cell...