Gasdermin-mediated pyroptosis as a prognostic biomarker and therapeutic target in hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) develops within a chronically inflamed and immunologically dysregulated hepatic microenvironment that contributes to therapeutic resistance and disease progression. Gasdermin-mediated pyroptosis has emerged as a context-dependent inflammatory cell-death program capable of reshaping antitu...