Plant mitochondria share many features with animal mitochondria but also possess unique traits, including presence of both circular and linear mitochondrial DNA, RNA editing, a branched electron transport chain, and metabolic pathways supporting photosynthesis. An accurate mitochondrial proteome is crucial for studying...
Minsoo Kim, Sarah E. Calvo, Khanh Nguyen et al.· Cell· 5 citations
SUMMARY Oxidative phosphorylation (OXPHOS) is a key metabolic process that couples redox energy to ATP production. While some core OXPHOS complex subunits are found across all domains of life, many have diverged or expanded across evolution—as seen in the protozoan pathogen Acanthamoeba castellanii. By integrating cryo...
Michelle Y. Fry, Bridget E. Luce, Jonathan A. Stefely et al.· Cell· 4 citations
SUMMARY Acanthamoeba castellanii causes infectious blindness and is a key evolutionary outgroup to humans and fungi. Its divergent mitochondria are of outstanding interest due to predicted aerobic and anaerobic functions with potential for drug targeting. However, a detailed delineation of its bioenergetic machinery, t...
Jonathan A. Stefely, Felicia Deng, Michael Z. Chen et al.· Cell· 6 citations
SUMMARY Giardia lamblia is a microaerophilic protozoan parasite that infects nearly 280 million people worldwide each year. Giardia lacks a mitochondrial genome and mitochondrial enzymes for oxidative phosphorylation. However, it retains mitochondrion-related organelles (MROs) that house an iron-sulfur cluster (ISC) as...
Manish Goyal, Tiana M. Issa, Jonathan A. Stefely et al.· Current Biology· 2 citations
Trypanosoma brucei and Leishmania tarentolae are model kinetoplastids whose mitochondria contain a unique DNA network, kinetoplast DNA (kDNA), and exhibit specialized features, including developmental remodeling and RNA editing. By integrating mass spectrometry-based protein correlation profiling with published dataset...
Andres F. Vacas, Md Solayman, Sarah E. Calvo et al.· Molecules and Cells· 4 citations
SUMMARY The mitochondrial proteomes of Leishmania tarentolae and Trypanosoma brucei contain ~1,700 proteins, most of which lack homologs in higher eukaryotes. Here, we integrate complexome profiling and cryo-electron microscopy to define conserved and lineage-specific macromolecular assemblies that support mitochondria...
Md Solayman, Yi-Ting Liao, Sarah E. Calvo et al.· Molecules and Cells· 2 citations
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