Claudin-5 regulates mitochondrial bioenergetics and protects the heart against myocardial infarction.
AAV-mediated overexpression of Cldn5 significantly protected the heart against ischemic injury by reducing infarct size, preserving mitochondrial number, preserving mitochondrial number, decreasing ADP/ATP ratio and mitochondrial ROS production, and enhancing the signal of energy metabolism and mitochondrial biogenesis...