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Author

Naoko Matsumoto

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Open access Aug 2026

Two Japanese Cases Highlighting Structural and Phenotypic Overlap in AGO1- and AGO2-Related Neurodevelopmental Disorders.

Structural assessment using AlphaFold2-based AGO1 models and the AGO2 crystal structure confirmed positional equivalence of the affected residues, supporting the concept of a shared structural vulnerability across Argonaute paralogs and highlighting RNA-regulatory dysfunction as a coherent pathogenic axis.

Munetsugu Hara, Nobuhiko Okamoto, Yukihiro Kitai et al. · 0 citations
Aug 2026

Imbalanced p53–RB signaling triggers cGAS–STING–mediated immune activation in early oral cancer development

Analysis of the TCGA-HNSC cohort showed that combined TP53/CDKN2A alterations significantly separated overall survival and were associated with distinct survival patterns, revealing a previously unrecognized mechanism by which imbalanced p53-RB signaling triggers tumor immunity during the early stages of oral carcinoge...

Zi-Chao Lu, Yasuhiro Mouri, Wenhua Shao et al. · 0 citations

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