Author

Narcís Fernandez-Fuentes

2 papers indexed here

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Open access Sep 2026

Dual targeting of CD244 and CD2 by a viral-immunoevasin-guided engineered CD48-Fc mutant for T- and NK-cell modulation

Viruses encode immunoevasins that subvert host co-signaling pathways. CD244:CD48 and CD2:CD58 interactions are critical for NK- and T-cell effector responses. We previously identified a herpesvirus-encoded soluble CD48 homolog that functions as a decoy ligand for CD244 and dampens NK-cell activation. Here, we show that...

Olga Bautista-Cerecero, P. Hernández-Luis, Pablo Martínez-Vicente et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

Tisa-cel and axi-cel CAR structure influences the development of resistance to CD19-CAR-T therapy.

It is shown that CAR structure is a critical determinant of CD19 loss in tumor B cells, and Mathematical modeling indicates that the failure of CD19-4-1BB-based CAR-T cells to eliminate CD19low cells, unlike CD28-based CARs, promotes the expansion of resistant populations.

Marta Krawczyk, K. Fidyt, Narcís Fernandez-Fuentes et al. · Leukemia · 0 citations