DEVELOPMENT AND OPTIMIZATION OF ANTICANCER DRUG NANOCRYSTALS USING A QUALITY BY DESIGN APPROACH TO IMPROVE SOLUBILITY AND DISSOLUTION PERFORMANCE
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Background: Cisplatin is an effective chemotherapeutic agent; however, its clinical application is limited by poor aqueous solubility, low cellular uptake, and suboptimal biopharmaceutical performance. Nanocrystal technology offers a promising strategy to overcome these limitations by enhancing dissolution and intracel...
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