Author

Natali L. Chanaday

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Open access Sep 2026

Synaptobrevin‐2 Containing Extracellular Vesicles Are Rapidly Incorporated Into Mammalian Neurons via a Dynamin‐Dependent Pathway

Synaptobrevin‐2 (Syb2) is a SNARE protein essential for neurotransmitter release and communication in the nervous system. We previously showed that Syb2 is also exchanged among neurons via extracellular vesicles (EVs). Host neurons rapidly integrate exogenous Syb2 into their synaptic vesicle cycle to support neurotrans...

Victoria Hannett, A. Vilcaes, S. Hugelier et al. · Journal of Neurochemistry · 0 citations

Open access Aug 2026

Astrocytes mobilize a broader repertoire of lysosomal repair mechanisms than neurons

Summary Lysosomal damage impairs proteostasis and contributes to neurodegenerative diseases, yet cell-type-specific differences in lysosomal repair remain unclear. Using a neuron-astrocyte coculture system, we compared responses to lysosomal injury induced by a lysosomotropic methyl ester. Both neurons and astrocytes s...

Erin M. Smith, Natali L. Chanaday, S. Maday · iScience · 0 citations