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Author

Natasha Sieczkiewicz

1 paper indexed here

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Open access Aug 2026

cGAS-deficient mice display premature aging associated with derepression of LINE1 elements and inflammation

Aging-associated inflammation is a driver of multiple age-associated diseases. Cyclic GMP–AMP synthase (cGAS) contributes to inflammaging by responding to endogenously-derived cytoplasmic DNA in aged cells. Although cGAS-knockout (KO) mice are viable, their aging has not been characterized. Unexpectedly, we found that...

John C. Martinez, Francesco Morandini, Cheyenne Rechsteiner et al. · 2 citations

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