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Emerging trends in nanomedicine: The role of RNAi-based therapies and onpattro’s clinical journey
Onpattro, the first FDA-approved RNAi therapy, is highlighted, Onpattro’s clinical development is highlighted, compares delivery platforms, discusses translational challenges, and emerging technologies that will guide the next generation of RNAi nanomedicines in personalized therapy are examined.
Nanofabrication of shikonin accelerates the wound healing potential in diabetic rats via downregulation of MMP-9: in vitro/in vivo pharmacological validation and in silico molecular dynamic approach
The developed system with remarkable wound healing potential was displayed, displaying chemical stability, improved aqueous solubility and wound area reduction in the present study.