Author

Nelson H. Knudsen

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Open access Oct 2026

A Lenalidomide-Inducible Suicide Switch for Gene- and Cell-Based Therapy

Genetically modified immune effector cells, including chimeric antigen receptor (CAR) T cells, have emerged as transformative anti-cancer agents. However, these autonomous, living therapies are limited by difficult-to-control hyperactivation toxicities. To achieve their full potential as therapies for a broader range o...

Ditsa Sarkar, William Lin, Nelson H. Knudsen et al. · bioRxiv · 0 citations

Jul 2026

CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer.

These findings highlight Dusp5 and Zfp219 as critical drivers of age-related T cell dysfunction that can be targeted to rejuvenate antitumor immunity in older cancer patients.

Alex C. Y. Chen, Keely Y. Ji, C. Yerinde et al. · Cell · 0 citations