Author

Neni Frimayanti

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Sep 2026

Anti‐ Candida Flavonoid Leads: Mechanistic Evaluation and Early Safety Assessment

Candida infections remain difficult to treat because of antifungal resistance, toxicity, and suboptimal pharmacokinetics. This study comparatively evaluated fourteen structurally diverse flavonoids against Candida albicans , Candida glabrata , and Candida krusei to identify structure–activity, mechanistic, a...

H. Y. Teruna, Fauzan Zein Muttaqin, Neni Frimayanti et al. · ChemistrySelect · 0 citations

Open access Aug 2026

Design and mechanistic evaluation of chalcone–quinoline–triazole hybrids as antifungal CYP51 inhibitors

Mechanistic investigations demonstrated that compound 7b markedly disrupted fungal sterol biosynthesis, as evidenced by significant ergosterol depletion, lanosterol accumulation, and a pronounced reduction in the ergosterol/lanosterol ratio across all tested Candida species.

R. Hendra, Rahmad Setiawan Rabby, Tengku Anggia Fitri et al. · Medicinal Chemistry Research · 0 citations

Open access Jul 2026

In vitro and in silico Investigation of Bioactive Compounds from Arcangelisia flava (L.) Merr. as Potential Antibacterial Agents

The growing threat of antibiotic resistance has prompted the hunt for new antibacterial medicines derived from natural sources. This work examined four compounds isolated from Arcangelisia flava (L.) Merr. roots: palmatine (1), fibraurin (2), β-sitosterol (3), and daucosterol (4). Both in vitro and in silico methods we...

Neni Frimayanti, Ihsan Ikhtiarudin, J. Jasril et al. · Sains Malaysiana · 0 citations