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Nermin Keni Begendi

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Open access Oct 2026

Enhanced Antileukemic Efficacy of Venetoclax-Loaded PEG-PLGA Nanoparticles Against THP-1 Acute Monocytic Leukemia Cells via Suppression of BCL-2 and Pro-Survival Signaling Pathways

Background: Acute myeloid leukemia (AML) presents a significant therapeutic challenge due to the systemic toxicity associated with traditional chemotherapy. Venetoclax, a selective BCL-2 inhibitor, has shown promising antileukemic activity; however, limited pharmacokinetic properties impair its clinical use. Polymeric...

Nermin Keni Begendi, E. Kaga · 0 citations

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