Tailored [1,2,4]triazolo[1,5-a]pyrimidine hybrids as promising anti-inflammatory agents with COX/5-LOX/ROS/IL-6 multifunctional inhibitory activity: design, synthesis, SAR, and in silico study
To develop potent anti-inflammatory agents with safer profiles, a hybridization approach combining [1,2,4]triazolo[1,5-a]pyrimidine/chalcone (5a–g) and [1,2,4]triazolo[1,5-a]pyrimidine/pyrazole (6a–g) has been rationally designed to synthesize potential COX/5-LOX/ROS/IL-6 multifunctional inhibitors. All synthesized hyb...