Author

Nesreen K Al-Jezawi

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Open access Aug 2026

Neurabin I haploinsufficiency disrupts ion channel regulation and synaptic maturation in human cortical neurons in neurodevelopmental disorders.

The first comprehensive human mechanistic model of PPP1R9A haploinsufficiency using an isogenic CRISPR/Cas9-engineered iPSC system differentiated into cortical neurons is established, providing a human-specific mechanistic framework linking reduced Neurabin I dosage to neurodevelopmental and psychiatric disease risk.

Binte Zehra, Nesrin Mohamed, Richa Tambi et al. · Molecular Psychiatry · 0 citations