Open access
Aug 2026
A CK2α–G3BP1 signaling axis regulates local translation in developing neurons and is disrupted in OCNDS
Findings establish OCNDS as a disorder of compartment-specific translational dysregulation driven by impaired CK2α–G3BP1 control of RNA granule homeostasis, and establish G3bp1 knockdown rescues translational and morphological phenotypes across all OCNDS alleles.
Manasi Agrawal, Meghal Desai, Shruti Ghumra et al.
· bioRxiv · 0 citations