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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Nicholaas Stahl

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Sep 2026

Discovery of Tetrasubstituted Quinazolin-4(3H)-ones as Wild-type-sparing, Highly Selective PI3KαH1047R Inhibitors.

Inhibiting PI3Kα has demonstrated promising therapeutic effects for patients with HR+/HER2- and PIK3CA-mutated advanced or metastatic breast cancer. However, hyperglycemia and other notable adverse events (AE) associated with concomitant wild-type inhibition remain a challenge and limit dosing. Selectively targeting th...

Chun Chen, R. Holmes, Jack Carter et al. · 0 citations

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