Author

Nicholas C. Wu

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Open access Oct 2026

Antibodies targeting a conserved cryptic epitope at the influenza hemagglutinin head-stem interface via distinct binding modes

Influenza A virus continues to pose pandemic threats, as demonstrated by the recent global spread of highly pathogenic H5N1 strains. Consequently, the development and characterization of vaccines targeting zoonotic influenza subtypes have become a major focus of the field. In this study, we characterize two broadly rea...

Guthrie L. Stroh, Hui-Bin Lv, Chun-Ke Chen et al. · bioRxiv · 0 citations

Open access Sep 2026

Epistasis and pleiotropy constrain the evolution of cross-reactive breadth in a broadly neutralizing influenza antibody

The findings provide a mechanistic explanation for the scarcity of HA stem bnAbs with cross-reactivity against both influenza A and B viruses, and have important implications for developing broadly protective influenza vaccines.

Katrine E. Dailey, Yi-Quan Wang, Q. Teo et al. · PLoS Biology · 0 citations

Open access Jul 2026

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

The structural basis by which specific mutations enhance cross‐variant recognition of SARS‐CoV‐2 is defined, highlighting the underappreciated breadth encoded within the naïve B‐cell repertoire and providing a conceptual framework for engineering and eliciting antibody responses resilient to future antigenic drift.

Huibin Lv, Ziqi Feng, Q. Teo et al. · Advancement of science · 0 citations