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Author

Nicholas H. Stillman

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Open access Sep 2026

Synthesis of Large- and Medium-Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular SNAr.

We report the first examples of catalytic, intramolecular N-heterocycle arylation by nucleophilic aromatic substitution (SNAr), a general method for synthesis of highly strained macrocycles and medium-sized heterobiaryl atropisomeric rings. Key to the approach is the ability to generate a strong base catalytically, as...

Alireza Abbasi Kejani, Paritosh Dey, Nicholas H. Stillman et al. · 0 citations

Synthetic Protein Mimetic Based Therapies for Neurodegeneration

The ability of the 2D-FAST to discover potent antagonists of pathological proteins related to a wide range of diseases, including Alzheimer’s disease, is demonstrated.

Nicholas H. Stillman · 0 citations

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