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Author

Nicholas L. Yan

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Aug 2026

Substrate Mimicry by Inhibitors of the Mycobacterium tuberculosis 20S Proteasome and Their Activity against Mycobacteria In Vitro and in Macrophages

The remarkable and problematic capacity of Mycobacterium tuberculosis to persist in the host is dependent on a functional 20S proteasome that is structurally and functionally analogous to its mammalian counterpart. It has been proposed that this enzyme is critical for the bacterium’s adaptive response to a variety of...

Xilin Gu, Peter J. Rowheder, Zanlin Yu et al. · 0 citations
Open access Sep 2026

Cryo-EM Structures of Infectious Low-Twist α-Synuclein Filaments in Lewy Bodies

It is established that low-twist filaments, which include over 75% of disease-associated Lewy aSyn amyloids, share a common structural core with high-twist forms and are the predominant aSyn species in samples that engage in templated infection.

Nicholas L. Yan, Mylan Mayer, Arthur A. Melo et al. · 0 citations
Open access Aug 2026

Cofactor-Free Tau Filaments Are Dynamic and Undergo Structural Evolution Driven by Thermodynamic Control

Environmental factors, such as mechanical stress and/or polyanions, play an important role in promoting the thermodynamic stability of otherwise dynamic tau fibrils, and it is speculated that, in patients, such factors might contribute to the maturation of disease-specific conformers.

Wyatt C. Powell, Nicholas L. Yan, Eric Tse et al. · 0 citations

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