Author

Nichollas E. Scott

3 papers indexed here

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Open access Oct 2026

An Expanded Lpt Pathway Couples Surface Lipoprotein Export to Outer Membrane Vesicle Biogenesis in Bacteroides

The ecological dominance of Bacteroidota in the human gut microbiota derives from their exceptional capacity to metabolize diverse dietary and host-derived glycans. This ability relies on surface-exposed lipoproteins (SLPs), which are displayed on the bacterial surface and selectively packaged into outer membrane vesic...

Biswanath Jana, Evan J. Pardue, Teng-Fei Zhong et al. · bioRxiv · 0 citations

Open access Aug 2026

Functional immune changes are conserved in COVID-19 and trauma patients receiving intensive care

Critical illness, including COVID-19 and trauma, induce immune dysregulation associated with morbidity and mortality. Direct comparison is crucial to identify shared pathobiological mechanisms to guide precision therapies. This prospective cohort study undertook a comprehensive, longitudinal comparison of innate immune...

Alexander J. T. Wood, G. Albers, Willem Cornelissen et al. · Nature Communications · 0 citations

Open access Sep 2026

Temporal N-terminomics analysis reveals proteome remodeling following brensocatib-mediated cathepsin C inhibition in promyeloblast cells

Cathepsin C (CatC) is known to activate neutrophil serine proteases (NSPs) involved in innate immune function, although its broader impact on cellular proteolytic networks remains poorly defined. Here, we characterized the proteolytic landscape of HL-60 neutrophil progenitor cells following treatment with the CatC inhi...

Yi-Min Zhu, Stephan Luedtke, Bang-Yan Xu et al. · bioRxiv · 0 citations