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Nicky Thomas

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Open access Aug 2026

Cationic metal-binding coumarin amphiphiles as membrane-active antimicrobial agents.

The results suggest that incorporating metal-binding headgroups into amphiphilic scaffolds may engage a distinct mode of action compared to traditional small-molecule AMP mimetics, resulting in increased antimicrobial potency and selectivity over mammalian membranes.

Samuel O. Nitschke, Anteneh Amsalu, Muhammed Awad et al. · 0 citations