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Author

Nicolas S. Merle

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Open access Jul 2026

Inherited C5aR2 deficiency leads to uncontrolled inflammatory T cell responses and autoinflammatory disease 2309676

A previously unrecognized CPM-dependent mechanism that balances C5aR1 and C5aR2 signaling to limit pathological T cell activation is uncovered, revealing an intrinsic complement-driven checkpoint that constrains effector T cell immunity.

Erin E. West, Nicolas S. Merle, Ayden Case et al. · 0 citations

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